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ph~1染色体(ph~1)是自Nowell和Hungerford1960年首次描述以来研究得最深入的一种白血病细胞遗传学标志。最初认为是慢性髓细胞白血病(chronic myelocytic leukemia,CML)特有的染色体,后来在其它疾病中也已发现,包括骨髓增殖性疾患和急性淋巴细胞白血病(acute lymphocytic leukemia ALL)。本文报道1例儿童急性T细胞白血病(TALL),在病程后期癌细胞中发生ph~1。患儿5岁,男,于1980年11月因活动减少、食欲下降、苍白、青紫1周就诊。有严重瘀斑,颈部和腋下淋巴结肿大,肝脾仅可触及,胸部X线显示前纵隔
The ph ~ 1 chromosome (ph ~ 1) is a transcript of the knowledge that has been studied since Nowell and Hungerford in 1960. Originally thought to be a chromosome specific for chronic myelocytic leukemia (CML), it has also been found in other diseases, including myeloproliferative disorders and acute lymphocytic leukemia ALL. This paper reports a case of childhood acute T cell leukemia (TALL), in the course of the disease occurred in the ph ~ 1 cells. Children 5 years old, male, in November 1980 due to reduced activity, loss of appetite, pale, bruising 1 week treatment. Severe ecchymosis, neck and armpit lymph nodes, liver and spleen only accessible, chest X-ray showed the anterior mediastinum