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从柴胡Bupleurtim falcatum L.根中提取的柴胡皂甙,对炎症初期血管通透性亢进有抑制作用,并且在抑制右旋糖酐(Dextran)所致浮肿的同时,尚有抗肉芽形成的作用。以柴胡为中心的方剂柴苓汤、小柴胡汤、TJ-8014(小柴胡汤去生姜加黄连、茯苓)对小鼠抗GBM肾炎、加速型passive Heymann肾炎及Puromycin aminonucleoside肾病均有治疗效果。本次实验主要研究柴胡成分柴胡皂甙用于豚鼠抗GBM肾炎(anti-GBM nephritis)的效果。同时探讨了其作用机制方面的内容,如柴胡皂甙对血小板聚集力、内源性皮质酮(corti-
The saikosaponin extracted from the Bupleurtim falcatum L. roots of Bupleurum chinense inhibited the inflammatory hyperpermeability at the initial stage of inflammation and inhibited the edema induced by Dextran, but at the same time, it had anti-granulogenesis effect. Chaibutang, Xiaochaihutang, and TJ-8014 (Chaihuhu Decoction plus Coptis chinensis, Radix paeoniae Alba), which are centered on Bupleurum, have therapeutic effects on anti-GBM nephritis, accelerated passive Heymann nephritis, and Puromycin aminonucleoside nephropathy in mice. This experiment mainly studied the effect of saikosaponin saikosaponin on guinea pig anti-GBM nephritis. At the same time, its mechanism of action, such as saikosaponin on platelet aggregation and endogenous corticosteroids (corti-