目的　探讨妊娠期甲基汞暴露对大鼠的母体毒性效应。方法　用不同剂量甲基汞〔0 .0 0、0 .0 1、0 .0 5、2 .0 0mg/ (kg·d)〕于 Wistar大鼠孕 6～ 9天时连续 4天灌胃染毒 ,观察母鼠妊娠期、哺乳期的各种生理、生育过程 ,脑组织形态学和单胺类神经递质 (去甲肾上腺素、多巴胺、5 -羟色胺 )等指标。结果　与对照组相比 ,暴露组母鼠脑组织中单胺类神经递质的含量明显增高 (P<0 .0 1) ,呈现出剂量 -效应关系 (等级相关系数 rs分别为 0 .712 ,0 .90 3,0 .92 6 ) ,P均 <0 .0 1;其余指标未见明显异常。结论　本实验剂量下 ,妊娠期甲基汞暴露对大鼠的母体毒性尽管十分微弱 ,但母体脑组织的化学损伤已经发生。 Objective To investigate the maternal toxic effects of methylmercury exposure during pregnancy. Methods Methylmercury (0,0,0,0,01,0,05,2. 0 0 mg / (kg · d)] was administered intragastrically in the Wistar rats for 6 ~ 9 days during pregnancy. The physiological and reproductive processes during pregnancy and lactation were observed. The brain histomorphology and monoamine neurotransmitters (norepinephrine, dopamine and serotonin) were observed. Results Compared with the control group, the levels of monoamine neurotransmitters in the brain tissues of exposed females were significantly increased (P <0.01), showing a dose-response relationship (rank correlation coefficient rs = 0. 712, 0 .90 3,0 .92 6), P <0.01; the other indicators no significant abnormalities. Conclusion Although the maternal toxicity of methylmercury exposure during pregnancy in pregnant rats is very weak, the chemical damage of maternal brain tissue has occurred.