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目的探讨利福喷丁联合左氧氟沙星在初治菌阳肺结核患者中的疗效。方法 85例菌阳肺结核患者,按随机数字表法分为对照组(42例)与观察组(43例)。给予对照组2HRZE/4HRE方案治疗,给予观察组2HL2ZV/4HL2V方案治疗。比较两组治疗效果。结果观察组患者痰菌检测转阴率高于对照组(P<0.05);观察组患者治疗总有效率为90.70%高于对照组的69.05%,且观察组患者不良反应发生率低于对照组,差异均具有统计学意义(P<0.05)。结论利福喷丁联合左氧氟沙星在初治菌阳肺结核中效果显著,值得临床推广应用。
Objective To investigate the efficacy of rifapentine combined with levofloxacin in patients with newly diagnosed bacillary positive pulmonary tuberculosis. Methods Eighty - five patients with bacillary positive pulmonary tuberculosis were divided into control group (n = 42) and observation group (n = 43) according to random number table method. The control group was treated with 2HRZE / 4HRE regimen and the observation group was treated with 2HL2ZV / 4HL2V regimen. Compare the treatment effect of two groups. Results The negative rate of sputum test in the observation group was higher than that in the control group (P <0.05). The total effective rate in the observation group was 90.70% higher than that in the control group, and the incidence of adverse reactions in the observation group was lower than that in the control group , The differences were statistically significant (P <0.05). Conclusion The combination of rifapentine and levofloxacin is effective in the initial treatment of bacillary positive pulmonary tuberculosis and is worthy of clinical application.