论文部分内容阅读
目的探讨婴儿病理性黄疸时血清胆汁酸的变化及其临床意义。方法采用酶法测定253例婴儿各类病理性黄疸的血清胆汁酸(TBA)水平,进行相互比较分析,并与其它肝功能指标比较。结果各类病理性黄疸中,TBA升高以肝炎组和胆道闭锁组最明显,感染组、溶血组、窒息组次之,母乳性黄疸组最低;ALT在肝炎组和胆道闭锁组有明显升高,在其它四组则无一例升高;AST、γGT在肝炎组和胆道闭锁组有显著升高,但变化范围大;在其它四组普遍升高,程度较正常值约升高二倍左右。结论病理性黄疸时胆汁淤积加重,其程度以肝炎和胆道闭锁最重,感染、溶血、窒息因素次之,母乳因素最轻;肝炎、胆道闭锁时存在肝细胞损伤,而其它病理性黄疸时肝细胞损伤不大;TBA较其它肝功能指标更有特异性。
Objective To investigate the changes of serum bile acid in infants with pathological jaundice and its clinical significance. Methods Serum bile acid (TBA) was measured by enzymatic method in 253 infants with various pathological jaundice. The levels of TBA were compared with each other and compared with other liver function indexes. Results In all kinds of pathological jaundice, the increase of TBA was the most obvious in hepatitis group and biliary atresia group, followed by infection group, hemolysis group and asphyxia group, the lowest in breast milk jaundice group. ALT was significantly increased in hepatitis group and biliary atresia group , While no increase in the other four groups; AST, γGT in hepatitis group and biliary atresia group were significantly increased, but the range of change; in the other four groups generally increased, about twice the normal level of about. Conclusions Pathological jaundice aggravates cholestasis, with the degree of hepatitis and biliary atresia being the most serious, followed by infection, hemolysis and asphyxia, and the least factors of breast milk. Hepatitis and biliary atresia have liver cell injury, while other pathological jaundice when liver Little damage to cells; TBA is more specific than other indicators of liver function.