目的:考察5个不同厂家那格列奈片的溶出度情况。方法:采用转篮法进行体外溶出度试验,以pH 6.6的磷酸盐缓冲溶液为溶出介质,HPLC法进行含量测定。结果:有4个厂家的那格列奈片在45 min时溶出度达到70%以上,一个厂家的那格列奈片溶出度仅为27.72%。结论:5个不同厂家那格列奈片的溶出度参数有明显差异,临床应用时应加以注意。 Objective: To investigate the dissolution of nateglinide tablets from 5 different manufacturers. Methods: In vitro dissolution test was carried out by the basket spinning method. The phosphate buffered saline (pH 6.6) was used as dissolution medium and the content was determined by HPLC method. RESULTS: Nateglinide tablets from 4 manufacturers reached more than 70% dissolution at 45 min. The dissolution rate of nateglinide in one manufacturer was only 27.72%. Conclusion: The dissolution parameters of nateglinide in five different manufacturers are obviously different, which should be paid attention to in clinical application.