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热休克蛋白 70 (HSP70 )家族是一类重要的应激蛋白 ,在肿瘤组织中可诱导其异常表达。由于HSP70在肿瘤免疫中发挥免疫佐剂的功能 ,并介导细胞免疫 ,协同抗原提呈细胞、αβT细胞、γδT细胞和NK细胞的作用 ,综合多种免疫效应杀伤肿瘤细胞 ,表明HSP70对开发肿瘤疫苗有重要的意义
Heat shock protein 70 (HSP70) family is an important class of stress proteins that can induce abnormal expression in tumor tissues. Because HSP70 plays an immune adjuvant function in tumor immunity and mediates the effects of cellular immunity, synergistic antigen presenting cells, αβT cells, γδT cells and NK cells, it can kill tumor cells by multiple immunological effects, indicating that HSP70 plays an important role in tumor development Vaccines have important implications