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美国每年有几十万病人接受单纯的抗癌药化疗。几千人从事抗癌药的制造、配制、管理和使用,也可能潜在接触这些抗癌药。因此,健康人应当防止任何在制造和使用中接触抗癌药所带来的毫无必要的危害。抗癌药作用的主要原理是中止恶性细胞的增生,而对正常细胞的危害应尽可能小。作用于有丝分裂前的抗癌药包括抗代谢药(即合成叶酸、嘌呤嘧啶,或核苷酸的拮抗剂),各种干扰转录过程的抗菌素和主要通过烷化作用损害DNA及其他亲核物质的烷化剂(例:氮芥
Hundreds of thousands of patients in the United States receive a simple anticancer drug every year. Thousands of people engaged in the manufacture, formulation, management and use of anticancer drugs may also potentially have access to these anticancer drugs. Therefore, healthy people should prevent any unnecessary harm brought by exposure to anticancer drugs during their manufacture and use. The main principle of anticancer drug effect is to stop the proliferation of malignant cells, while the harm to normal cells should be as small as possible. Anticancer drugs that act on pre mitosis include antimetabolites (ie, synthetic folic acid, purine pyrimidine, or antagonists of nucleotides), various antibiotics that interfere with the transcription process, and damage to DNA and other nucleophiles primarily through alkylation Alkylating agents (example: nitrogen mustard