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为了评价米索前列醇阴道给药用于中、晚期妊娠（简称中孕及晚孕）促宫颈成熟及引产对胎儿的安全性,采用随机双育法,比较试验组与对照组（晚孕对照组用安慰剂,中孕对照组用利凡诺）终止妊娠后胎盘大体解剖、光镜结构变化,观察米索前列醇用于晚孕促宫颈成熟及引产对胎盘结构的影响;同时也观察比较米索前列醇和利凡诺终止中孕时对胎盘结构的影响。结果表明,米索前列醇能较快地促进宫颈成熟并在短时间促发临产,也可较快地致中孕引产而分娩有生机儿。所娩出胎盘胎膜完整,胎盘组织无明显出血灶。光镜观察,该药不致绒毛水肿、滋养细胞及蜕膜组织变性坏死,绒毛无明显结节形成细胞出芽。但见绒毛干及绒毛血管不同程度扩张、绒毛膜板有不同程度炎性细胞浸润,此种改变属正常生理反应及（或）良性药理效应.不影响胎盘生理功能,对胎儿是安全的。
In order to evaluate the vaginal administration of misoprostol for middle and late pregnancy (referred to as middle and late pregnancy) to promote cervical ripening and induction of labor on the safety of fetus, randomized double-yin method was used to compare the experimental group with the control group Group control group with rifampicin, pregnant women control group with rivanol) termination of pregnancy after placenta gross anatomy, light microscopy structural changes observed misoprostol for late pregnancy to promote cervical maturation and induction of labor on placental structure; also observed and compared Effects of misoprostol and rivanol on placental structure when termination of second trimester. The results showed that misoprostol can quickly promote cervical maturation and in a short time to induce labor, but also can lead to faster pregnancy induced labor with childbirth. The placenta delivered by the fetal membrane integrity, placental tissue no obvious hemorrhage. Light microscopic observation, the drug does not villiate edema, degeneration and necrosis of trophoblastic and decidual tissue, villus no obvious nodular formation of budding. However, see the villus dry and villus vascular expansion to varying degrees, the chorionic plate has varying degrees of inflammatory cell infiltration, this change is a normal physiological reaction and (or) benign pharmacological effects. Does not affect the physiological function of the placenta, the fetus is safe.