论文部分内容阅读
为探讨慢性化脓性中耳炎影响内耳听觉功能的机理。统计了２００例、２４０耳慢性化脓性中耳炎（ＣＯＭ）患者的病史、纯音测听、乳突拍片和ＣＴ扫描的结果；并对中耳病变与耳聋性质及程度的关系，进行分析。制备化脓性中耳炎豚鼠１２只、１５耳，在光镜及电镜下观察耳蜗Ｃｏｒｔｉ′ｓ器外毛细胞的病理变化。结果：本组患者合并感音性聋（ＳＮＨＬ）１０７耳，占４４．６％；病史５年以内及５年以上ＳＮＨＬ合并率分别为２８．５％和６３．６％，差异有高度显著性（Ｐ＜０．０１）；中耳病变Ⅰ型及Ⅱ～Ⅲ型ＣＯＭ患者ＳＮＨＬ合并率为２７．９％和８５．７％，差异有高度显著性（Ｐ＜０．０１）；观察ＣＯＭ豚鼠耳蜗Ｃｏｒｔｉ′ｓ器外毛细胞有病理损害。病史越长，中耳病变越重，耳蜗外毛细胞损害越重，ＳＮＨＬ合并率越高。
To investigate the mechanism of chronic suppurative otitis media affecting the auditory function of the inner ear. The clinical data of 200 patients with chronic suppurative otitis media (COM) in 240 ears were analyzed. The results of pure tone audiometry, mammography and CT scan were analyzed. The relationship between the nature and degree of middle ear lesion and deafness was also analyzed. Preparation of purulent otitis media guinea pigs 12, 15 ears, under light and electron microscopy Cochlear Corti’s external hair cells in the pathological changes. Results: There were 107 ears with sensory hearing loss (SNHL), accounting for 44.6%. The combined rates of SNHL within 5 years and over 5 years were 28.5% and 63.6% respectively, the difference was highly significant (P <0.01). The incidence of SNHL complicated by middle ear disease type Ⅰ and type Ⅱ ~ Ⅲ was 27.9% and 85.7%, respectively. The difference was highly significant (P0.01) Cochlear Corti’s external hair cells have pathological damage. The longer the history, the heavier the middle ear lesions, the more severe damage to the outer hair cells of the cochlea, the higher the rate of SNHL merger.