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目的 :为研究胃癌与激素之间的关系 ,本研究探讨了胃癌病人血清睾酮变化及其机理。方法 :应用放免法测定正常人、胃良性疾病和胃癌病人的血清睾酮、促间质细胞激素 (ICSH)。结果 :男性胃癌及胃良性疾病组血清睾酮、ICSH水平明显降低 ,但胃癌病人伴有出血和梗阻者血清睾酮、ICSH水平较同样胃良性疾病组病人降低更为明显。胃癌病人有出血和梗阻者血清睾酮、ICSH水平较不伴有并发症者降低更为明显。 期胃癌病人血清睾酮、ICSH水平与正常对照组对比显著降低。胃癌及胃良性疾病组血清睾酮、ISCH变化有显著相关性。结论 :1血清睾酮、ICSH水平可作为胃癌诊断的一个参考指标。 2胃癌及良性疾病血清睾酮、ICSH水平明显降低是由性腺轴抑制所引起。
Objective: To investigate the relationship between gastric cancer and hormones, this study explored the changes of serum testosterone in patients with gastric cancer and its mechanism. Methods: Serum testosterone and somatosensory stimulating hormone (ICSH) were measured in normal subjects, benign gastric diseases and gastric cancer patients by radioimmunoassay. Results: The levels of serum testosterone and ICSH in gastric cancer and gastric benign disease group were significantly lower than those in gastric benign disease group. However, the levels of serum testosterone and ICSH in patients with gastric cancer were significantly lower than those in the same gastric benign disease group. Gastric cancer patients with hemorrhage and obstruction of serum testosterone, ICSH levels lower than those without complications is more obvious. Serum testosterone and ICSH levels in patients with gastric cancer were significantly lower than those in normal controls. Gastric cancer and gastric benign disease group serum testosterone, ISCH changes have a significant correlation. Conclusion: 1 Serum testosterone, ICSH levels can be used as a reference indicator of gastric cancer diagnosis. 2 gastric cancer and benign diseases, serum testosterone, ICSH levels significantly reduced by the gonadal axis caused by inhibition.