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The title compound N 1-(1,3,4-thiadiazole-2-yl)-N 3-m-chlorobenzoyl-urea (C 9 H 7 N 4 OSCl,M r=254.70) was prepared by the reaction of m-chlorophenyl isocyanate with 2-amino-1,3,4-thiadiazole in dry acetonitrile.The effect of the title compound on tumor metastasis was analyzed by Lewis-lung-carcinoma model.The bioassay showed that the title compound significantly reduced the number of lung metastasis.The crystal structure has been determined by X-ray diffraction.The crystal belongs to the monoclinic system,space group P2 1 /c with a=11.565(2),b=9.5616(19),c=10.221(2),β=111.75(3)°,Z=4,V=1049.8(4)3,D c=1.612 Mg/m 3,F(000)=520,μ(MoKa)=0.544 mm-1,R=0.0468 and wR=0.0922 for 1236 observed reflections (I > 2σ(I)).
The title compound N 1- (1,3,4-thiadiazole-2-yl) -N 3 -m-chlorobenzoyl-urea (C 9 H 7 N 4 OSCl, M r = 254.70) was prepared by the reaction of m- chlorophenyl isocyanate with 2-amino-1,3,4-thiadiazole in dry acetonitrile. The effect of the title compound on tumor metastasis was analyzed by Lewis-lung-carcinoma model. bioassay showed that the title compound significantly reduced the number of lung metastasis. The crystal structure has been determined by X-ray diffraction. The crystal belongs to the monoclinic system with space group P2 1 / c with a = 11.565 (2), b = 9.5616 (19), c = 10.221 , β = 111.75 (3) °, Z = 4, V = 1049.8 (4) 3, D c = 1.612 Mg / m 3, F (000) = 520, μ (MoKa) = 0.544 mm -1, R = 0.0468 and wR = 0.0922 for 1236 observed reflections (I> 2σ (I)).