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观察中药热毒清对半乳糖胺敏化大鼠受内毒素致死性攻击后的保护作用。方法：模型组用半乳糖胺（０．３ｇｋｇ－１／只）和内毒素（１０μｇ／只）给大鼠作腹腔内注射，在此基础上，热毒清组和地塞米松组分别静注热毒清和地塞米松。结果：５小时后动物血中肿瘤坏死因子α、白细胞三烯Ｃ４、谷丙转氨酶和总胆红素水平均明显上升（Ｐ均＜０．０５）；在５～２０小时内大鼠全部死亡，死亡率为１００．００％。热毒清处理组的上述血液生化指标均明显低于模型组（Ｐ均＜０．０５），死亡率也低于模型组（５０．００％，Ｐ均＜０．０５）。结论：热毒清与地塞米松相似，具有良好的预防内毒素血症并发症的作用。
To observe the protective effects of traditional Chinese medicine Duduqing on galactosamine sensitized rats after endotoxin-lethal challenge. Methods: The rats in model group were intraperitoneally injected with galactosamine (0.3gkg-1 / only) and endotoxin (10μg / only). On the basis of this, the rats in Reduqing group and dexamethasone group were injected intravenously Detox and dexamethasone. Results: After 5 hours, the levels of tumor necrosis factor alpha, leukotriene C4, alanine aminotransferase and total bilirubin were significantly increased (all P <0.05); all rats died within 5 ~ 20 hours, The death rate was 100.00%. The above biochemical indexes of heat detoxification group were significantly lower than those of model group (all P <0.05), and the mortality rate was also lower than that of model group (50.00%, P <0.05). Conclusion: TCD is similar to dexamethasone and has a good effect in preventing the complications of endotoxemia.