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本文报道用差示分光光度法测定异烟肼(Ⅰ)及其制剂中的降解产物(致癌物及肝细胞毒物)——肼的含量。本法准确、灵敏、专一和快速。肼在盐酸溶液中与4-二甲胺基苯甲醛(Ⅱ)反应生成4-二甲胺基苄叉吖嗪衍生物(Ⅲ),其λmax为456nm;而在含丙酮的溶液中,反应生成无色二甲基甲酮连氮,使该溶液的A_(456)与盐酸溶液有一差值,等量肼(0～0.22μg·ml~(-1))的两溶液之Δ~456与肼的浓度呈线性关系。Ⅰ与Ⅱ也起反应生成
This paper reports the determination of the hydrazine content of isoniazid (Ⅰ) and its degradation products (carcinogens and hepatocyte toxicants) by differential spectrophotometry. This law is accurate, sensitive, specific and fast. Hydrazine in hydrochloric acid solution with 4-dimethylaminobenzaldehyde (Ⅱ) reaction 4-dimethylaminobenzofuran azine derivative (Ⅲ), its λmax is 456nm; and in the acetone-containing solution, the reaction generated There was a difference between the solution of A_ (456) and hydrochloric acid and the equivalent solution of Δ ~ 456 of hydrazine (0 ~ 0.22μg · ml ~ The concentration of a linear relationship. Ⅰ and Ⅱ also react to generate