论文部分内容阅读
目的探讨奥卡西平治疗儿童癫的疗效,并观察其药物不良反应。方法对129例各种类型癫患儿采用逐步加量法予口服奥卡西平,依据服药前发作频率分为2组。A组:服药前3个月内有3次以上发作的患儿在服用奥卡西平5个月后进行疗效的初始判断;B组:服药前1a发作3次以上者,服药1a后进行初始疗效判断。并观察药物不良反应及药物保留率。结果1.疗效判断:129例中能参加初始疗效判断的局限性发作癫患儿共60例。其中A组47例服药5个月后,发作完全控制者22例(45.8%),显效7例(14.6%),有效3例(6.3%),有效者共32例,有效率为66.7%;无效15例,无效率为33.3%。B组13例服药1a后,发作完全控制者12例(92.3%),无效1例(7.7%)。2组总计有效率为73.3%,无发作率为56.7%;单用奥卡西平治疗者,有效率为75.6%,无发作率为62.2%;联合用药者,有效率为66.7%,无发作率为40%。2.不良反应:31例(24%)患儿发现不良反应,但多数为一过性,症状轻微。3.药物保留率:1a药物保留率为72.2%,2a药物保留率为80%。结论奥卡西平具有满意的抗癫疗效,不良反应较轻微,药物保留率高,患者有较好的依从性和耐受性。
Objective To investigate the efficacy of oxcarbazepine in the treatment of children with epilepsy and to observe its adverse drug reactions. Methods A total of 129 children with epilepsy of various types were given oral oxcarbazepine step by step. According to the frequency of seizure before treatment, the patients were divided into two groups. Group A: the initial judgment of the curative effect of taking oxcarbazepine for 5 months in children who had 3 or more episodes within 3 months before taking the medicine; Group B: judgment. Adverse reactions and drug retention rates were observed. Results 1. Therapeutic judgments: 129 cases can participate in the initial evaluation of the efficacy of the limitations of the onset of epilepsy in children with a total of 60 cases. Among the 47 patients in group A, there were 22 cases (45.8%) with complete control and 7 cases (14.6%) were effective in 5 months after operation. The effective rate was 3 cases (6.3%), 32 cases were effective, and the effective rate was 66.7%. Invalid 15 cases, the inefficiency was 33.3%. Thirteen patients in group B took complete control for 12 patients (92.3%) and 1 patient (7.7%) after taking la for one year. The total effective rate was 73.3% in two groups, with no seizure rate of 56.7%. The single-use oxcarbazepine treatment rate was 75.6% with no seizure rate of 62.2%. The combination rate was 66.7% with no seizure rate 40%. Adverse reactions: 31 patients (24%) found adverse reactions in children, but the majority of transient, mild symptoms. 3. Drug Retention Rate: 1a drug retention rate was 72.2%, 2a drug retention rate of 80%. Conclusion oxcarbazepine has satisfactory anti-epileptic efficacy, mild adverse reactions, high drug retention, patients with better compliance and tolerance.