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目的:了解武汉地区血液病患者中庚型肝炎病毒(HGV)的感染情况,探讨HGV的传播途径。方法:采用酶联免疫吸附试验(ELISA)及逆转录聚合酶链反应(RT-PCR)方法测定各型血液病患者血清中的抗HGV和HGV RNA。结果:51例血液病患者中血清抗HGV阳性6例,占11.8％(5/61),HGV RNA均阴性。6例抗GHV阳性患者中急粒2例,占25%(2/8),慢粒1例,占50%(1/2),再障2例,占50％(2/4),粒细胞缺乏症1例,占100%(1/1)。6例抗HGV阳性患者均有受血史,占18.7%(6/32),显著多于无受血史者。6例抗HGV阳性患者有1例ALT升高,且发生在化疗结束后,与抗HGV阴性患者无显著性差异。结论:血液病患者中存在HGV感染,输血是其主要传播途径,且与受血次数呈正相关。HGV病毒血症时间短,为自限性,致病力弱,不单独引起肝损害,也不加重化疗所致的肝损害。
Objective: To understand the prevalence of hepatitis G virus (HGV) in patients with hematological diseases in Wuhan and to explore the route of transmission of HGV. Methods: Serum anti-HGV and HGV RNA were detected by enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR). Results: Serum anti-HGV was positive in 6 out of 51 patients with blood diseases (11.8%, 5/61). HGV RNA was negative. Among 6 anti-GHV positive patients, 2 cases were acute, accounting for 25% (2/8), 1 case was chronic, accounting for 50% (1/2), and aplastic anemia was 2 cases, accounting for 50% (2/4) 1 case of cell deficiency, accounting for 100% (1/1). 6 cases of anti-HGV positive patients have blood history, accounting for 18.7% (6/32), significantly more than those without blood history. One of six anti-HGV-positive patients had elevated ALT, which was not significantly different from anti-HGV-negative patients after chemotherapy. Conclusion: HGV infection exists in patients with hematological diseases. Blood transfusion is the main route of transmission and has a positive correlation with the number of blood transfusions. HGV viremia time is short, self-limiting, pathogenic weak, not alone cause liver damage, nor aggravate chemotherapy-induced liver damage.