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胰腺癌预后差,治疗主要是外科手术、化疗和放疗相结合的综合治疗,但目前常规治疗效果有限。分子生物学研究的进展,使人们对肿瘤发生发展机制的认识有了长足的进步,为胰腺癌的治疗开辟了新途径。自杀基因作为胰腺癌基因治疗中的一个重要研究方向,是近年来国内外学者研究的热点。本文拟对自杀基因在胰腺癌基因治疗中的研究现状及其进展作一综述。
Poor prognosis of pancreatic cancer, the main treatment is the combination of surgery, chemotherapy and radiotherapy combined treatment, but the current routine treatment is limited. Advances in molecular biology research, so that people have a great progress on understanding the mechanism of tumorigenesis, opened up a new way for the treatment of pancreatic cancer. As an important research direction in the gene therapy of pancreatic cancer, suicide gene is a hot spot in recent years both at home and abroad. This article intends to suicide gene in pancreatic cancer gene therapy research status and progress are reviewed.