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目的:观察格列美脲与格列吡嗪分别联合米格列醇治疗2型糖尿病的疗效。方法选取我院2013年~2014年门诊48例2型糖尿病患者,随机分为两组,观察组给予格列美脲联合米格列醇,对照组给予格列吡嗪联合米格列醇治疗。观察治疗前后空腹血糖(FBG)、三餐后2h (2hPG)、糖化血红蛋白(HbAlc)变化。结果格列美脲联合米格列醇患者耐受性、医从性更好,空腹及餐后血糖均较对照组有明显下降。结论格列美脲联合米格列醇控制血糖取得较好疗效,且患者不易漏服,医从性好。“,”Objective To observe the ef ect of glimepiride and glipizide associated migltol on type 2 diabetes. Methods From 2013 to 2014, 48 patients with type 2 diabetes in our hospital outpatient were selected and randomly divided into two groups, the observation group was given glimepiride associated migltol to treat, and the control group were given glipizide associated migltol to treat, before and after treatment, observing fasting blood glucose (FBG), 2 h after meals (2 HPG), glycosylated hemoglobin (HbAlc) change. Results The treatment of glimepiride associated migltol made patients have a good tolerance and a bet er obedience, postprandial blood glucose were compared with control group decreased obviously. Conclusion The treatment of glimepiride associated migltol has good curative ef ect, and the patient is not easy to leak, there is a bet er obedience.