目的 观察癌症患者化疗后细胞染色体发生畸变 的频度及畸变类型。方法 收集肺、胃、肝、胰、食管、结肠、卵巢和乳腺等器官的恶性肿瘤患者54例,男29例,女25例,平均53岁。在化疗前2天,结束后5天,用Tc199培养基培养外周血淋巴细胞,获取中期分裂的染色体,进行观察。结果 化疗前淋巴细胞染色体以 Objective To observe the frequency of chromosome aberrations and types of aberrations in cancer patients after chemotherapy. Methods 54 patients with malignant tumors of lung, stomach, liver, pancreas, esophagus, colon, ovary and breast were collected. There were 29 males and 25 females with an average age of 53 years. Two days before chemotherapy and five days after completion, peripheral blood lymphocytes were cultured with Tc199 medium to obtain metaphase chromosomes for observation. Results Pre-chemotherapy lymphocyte chromosomes