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目的 :探讨阻塞性睡眠呼吸暂停综合征 (OSAS)合并高血压患者的动态血压变化。方法 :经睡眠呼吸监测确诊后 ,对OSAS合并高血压患者 30例 ,单纯OSAS患者 2 4例进行 2 4h动态血压观察。结果 :(1)两组在性别、年龄、体重指数方面差异无显著性 (P >0 .0 5 ) ;(2 )OSAS合并高血压组的呼吸紊乱指数 (AHI)、血氧饱和度低于 90 %的时间百分比 (STL90 % )等睡眠呼吸检测结果均显著高于单纯OSAS组 ;(3)OSAS合并高血压组 2 4h平均收缩压及舒张压 (ASBP和ADBP)、晨起与睡前收缩压及舒张压 (SBP和DBP)均显著高于单纯OSAS组 ;(4 )OSAS合并高血压组晨起血压较睡前明显增高。结论 :睡眠呼吸紊乱和低氧血症是引起OSAS患者高血压形成的重要因素 ,OSAS合并高血压患者血压整体水平较高 ,晨起舒张压升高尤为明显。
Objective: To investigate the changes of ambulatory blood pressure in obstructive sleep apnea syndrome (OSAS) patients with hypertension. Methods: After confirmed by sleep-respiratory monitoring, 30 patients with OSAS complicated with hypertension and 24 patients with OSAS were observed for 24-hour ambulatory blood pressure. Results: (1) There was no significant difference in gender, age and body mass index between the two groups (P> 0.05). (2) The respiratory disturbance index (AHI) (3) The mean systolic and diastolic blood pressures (ASBP and ADBP) at 24 hours in OSAS patients with hypertension were significantly higher than those before sleep deprivation Diastolic blood pressure (SBP and DBP) were significantly higher than those in OSAS group alone. (4) The morning blood pressure was significantly higher in OSAS patients with hypertension than before sleep. Conclusion: Sleep-disordered breathing and hypoxemia are the important factors that cause the development of hypertension in patients with OSAS. The overall level of blood pressure is higher in OSAS patients with hypertension, especially in the morning.