小鼠感染克氏锥虫后的最初2个月为急性期,此时对特异性抗原的应咎及 B 细胞的多克隆激活作用均处于强烈的免疫抑制状态,这可能与自身抗体的出现有关。而后一阶段为漫长的慢性期,表现为虫数少但组织 The first 2 months after infection with Trypanosoma cruzi in mice is acute, at this time should be blamed for specific antigens and polyclonal activation of B cells are in a strong immunosuppressive state, which may be related to the emergence of autoantibodies . After a long period of chronic phase, the performance of the number of small but organized