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目的初步评估乳腺癌相关因子VEGF、MMP-9、PCNA与X-线钼靶征象间的关系。方法收集2005-2007年接受X线钼靶检查并经手术证实的乳腺癌40例,分析肿瘤的X线钼靶影像学征象与VEGF、MMP-9、PCNA蛋白表达的关系。结果间差异采用X2 test。结果直径>3cm、有明显分叶、有毛刺征的肿瘤的VEGF、MMP-9、PCNA的表达明显高于直径≤3cm、无明显分叶、无毛刺征的肿瘤。结论肿瘤相关因子VEGF、MMP-9、PCNA是判断乳腺癌生长、浸润的重要指标,X-线钼靶征象与VEGF、MMP-9、PCNA的表达密切相关,可为乳腺癌的治疗及预后提供参考。
Objective To evaluate the relationship between breast cancer related factors VEGF, MMP-9, PCNA and X-ray mammographic signs. Methods Forty breast cancer samples from 2005 to 2007 with mammography and surgically confirmed by X-ray were collected to analyze the relationship between the signs of mammography and the expression of VEGF, MMP-9 and PCNA. The difference between the results using X2 test. Results The diameter of tumor> 3cm, the tumor with obvious lobulation and burr sign was significantly higher than that of tumor with diameter less than or equal to 3cm, no obvious lobulation and no burr. Conclusions Tumor related factors VEGF, MMP-9 and PCNA are important indicators for the diagnosis of breast cancer. The signs of X-ray mammography are closely related to the expression of VEGF, MMP-9 and PCNA, which may provide the treatment and prognosis of breast cancer reference.