论文部分内容阅读
以往报道证明烧伤后粒细胞趋化、吞噬和杀菌能力减弱,超氧化物和过氧化氢产生是粒细胞功能丧失的表现。近年来进一步研究表明,虽然体外试验粒细胞的移动和趋化性表现异常,但其吞噬作用、杀菌能力和氧化活性的突发仍是正常的。粒细胞在体内被激活可使其氧化活性增强,但早期的激活可导致脱粒和细胞活性耗竭,如氧化活性增加氧化物释放可以造成继发性细胞功能障碍。本文研究热损伤以后所致不同烧伤面积及伤后不同时期与粒细胞氧化活性突发潜力的关系,研究对象是美国陆军外科研究收治的23名烧伤患者,平均年龄35.1±15.7岁,烧伤面积18～88％,平均41.6±16.8％,其中14名伴有吸入性损伤,总死亡率
Previous reports showed that after burn injury, granulocyte chemotaxis, phagocytosis and bactericidal ability weakened, superoxide and hydrogen peroxide production is a manifestation of loss of granulocyte function. In recent years, further studies have shown that although in vitro tests of granulocyte migration and chemotactic abnormalities, but its phagocytosis, bactericidal activity and oxidative activity of the burst is still normal. Granulocytes are activated in vivo to enhance their oxidative activity, but early activation can lead to degranulation and depletion of cellular activity, such as increased oxidative activity. Oxide release can cause secondary cellular dysfunction. This study was to investigate the relationship between the different burns area and the potential of sudden oxidative activity of granulocytes after heat injury. The study was performed on 23 burns patients treated by the U.S. Army Surgical Research, with an average age of 35.1 ± 15.7 years and a burn area of 18 ~ 88%, an average of 41.6 ± 16.8%, of which 14 accompanied by inhalation injury, total mortality