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英国发生了两例麻痹性脊髓灰质炎接触病例。病例1为1名16岁男孩(家庭接触者),在其侄女接种口服脊髓灰质炎疫苗后两周出现咽喉疼痛、恶心和厌食。4天后出现广泛性头痛和畏光,第5天出现轻度颈项强直,体温38℃,左臀呈弛缓性瘫痪,反射消失。血常规化验及抗体测定均为阴性,脑脊液检查发现,淋巴细胞1.5×10~7/1,蛋白浓度为0.33g/l,葡萄糖浓度为3.6mmol/1。入院时及14天和6周后测定血清脊髓灰质炎病毒抗体,1型和3型抗体滴度均低于1∶16;而2型抗体滴度则呈4倍以上增长(1∶64、1∶256和1∶1024)。大便培养证实为疫苗相关的2型脊髓灰质炎病毒株。该病人2天后全身
Two cases of paralytic polio contact occurred in the United Kingdom. Case 1 was a 16-year-old boy (domestic contact) who developed sore throat, nausea and anorexia two weeks after her niece’s oral polio vaccine. 4 days after the onset of extensive headache and photophobia, 5th day mild neck stiffness, body temperature 38 ℃, left hip flaccid paralysis, reflex disappeared. Blood tests and antibody tests were negative, CSF examination found that lymphocyte 1.5 × 10 ~ 7/1, the protein concentration of 0.33g / l, glucose concentration of 3.6mmol / 1. Serum poliovirus antibodies were measured at admission and at 14 and 6 weeks, with titers of type 1 and type 3 antibodies less than 1:16, while type 2 antibody titers increased more than 4-fold (1:64, 1 : 256 and 1:1024). Stool cultures were confirmed as vaccine-associated type 2 poliovirus strains. The patient 2 days after the whole body