痛觉是一种高度个体化的主观感受,在一定程度上取决于个体对痛经历和远期后果的整合。以往研究表明,幼年的痛经历显著影响成年后的痛觉。但是,成年的慢性痛经历是否影响远期的痛觉尚不清楚。Li等采用慢性炎症痛模型(成年大鼠足底注射完全弗氏佐剂,CFA),研究慢性痛对之后的福尔马林痛(急性痛)和痛相 Pain perception is a highly individualized subjective feeling, to a degree, depending on the individual’s integration of painful experiences and long-term consequences. Previous studies have shown that painful experiences in infancy significantly affect adult pain. However, it remains unclear whether adult chronic pain experiences long-term analgesia. Li and other chronic inflammatory pain model (adult rat foot injection of complete Freund’s adjuvant, CFA), the study of chronic pain after the formalin pain (acute pain) and pain phase