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患失天性甲状腺低功的婴儿,如果在生后3个月以前开始治疗,其精神发育可得到改善。由于新生儿甲状腺低功筛选试验的发展,通常于生后2个月之前即开始治疗。较早的资料提出,即使早期治疗的小儿也可表现神经心理学方面机能不全而妨碍发育。Glorieux等对一组3岁早期治疗的先天性甲状腺低功(以下简称CH)小儿进行研究,观察到患儿的Griffiths总智商(Griffiths发育试验)与治疗前所测定的血清T_4水平或骨龄之间,有显著的正相关。而且按听-说Griffiths标准,这些小儿早在18个月就比对照组的评分低。听力
An infant with atrophic hypothyroidism may have improved mental development if the treatment is started 3 months before birth. Due to the development of neonatal hypothyroidism screening tests, treatment is usually started 2 months after birth. Earlier data suggest that even early-treated children may exhibit neuropsychological insufficiency that hinders development. Glorieux et al studied a group of children with congenital hypothyroidism (CH) who were treated early at 3 years of age and observed that there was a significant difference between children with Griffiths total IQ (Griffiths development test) and serum T_4 level or bone age measured before treatment , There is a significant positive correlation. And according to the Griffiths standards, these children had a lower score than the control group as early as 18 months. hearing