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目的观察加替沙星与左氧氟沙星注射液治疗敏感性细菌引起的呼吸道感染的疗效与安全性。方法以左氧氟沙星注射液为对照,在60例受试者中进行了随机双盲、双模拟、平行对照试验。A组30例,每日给予加替沙星注射液400mg静脉滴注,2次/d;B组30例,每日给予左氧氟沙星注射液400mg静脉滴注,2次/d;治疗7d～14d。结果A组患者用药后临床痊愈率100%,有效率100%,B组患者用药后临床痊愈率93%,有效率93%。两组疗效比较,差异无显著性(p>0.05)。A组与B组的细菌清除率均为100%(p>0.05),两组不良反应发生率分别为13%与8%(p>0.05)。结论加替沙星注射液治疗呼吸道感染疗效及安全性与左氧氟沙星注射液相似。
Objective To observe the efficacy and safety of gatifloxacin and levofloxacin injection in the treatment of respiratory tract infections caused by susceptible bacteria. Methods Levofloxacin injection as a control, in 60 subjects were randomized double-blind, double-simulations, parallel controlled trials. A group of 30 patients were given daily gatifloxacin 400mg intravenous infusion, 2 times / d; B group 30 patients were given daily levofloxacin 400mg intravenous infusion, 2 times / d; treatment of 7d ~ 14d. Results In group A, the clinical cure rate was 100% and the effective rate was 100%. In group B, the clinical cure rate was 93% and the effective rate was 93%. There was no significant difference between the two groups (p> 0.05). The bacterial clearance rate of group A and group B was 100% (p> 0.05), and the incidence of adverse reactions was 13% and 8% in both groups (p> 0.05). Conclusion The efficacy and safety of gatifloxacin injection in the treatment of respiratory tract infection are similar to that of levofloxacin injection.