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目的初步研究生物转化酶类谷胱甘肽转硫酶M1(GSMT1)基因缺失多态性与海南中老年人群胃癌易感性的关系。方法收集某院中老年胃癌患者血液DNA130例作为实验组,体检科中老年健康体检者血液DNA138例作为对照组,利用PCR技术对所有的DNA样本进行GSTM1缺失多态性的检测。利用统计学软件SPSS13.0对数据进行统计学分析。结果 GSTM1(-)/GSTM1(+)在实验组中的检出率为29.8%/70.2%,在对照组中的检出率为18.8%/81.2%,两组间的数据经统计学分析差异有统计学意义(χ2=4.538,P=0.033﹤0.05)。结论 GSTM1基因缺失多态性与海南中老年人群胃癌易感性有关,GSTM1(-)可能是海南中老年胃癌患者的易感基因型。
Objective To study the relationship between the polymorphism of glutathione S-transferase M1 (GSMT1) gene and susceptibility to gastric cancer in middle-aged and elderly people in Hainan. Methods One hundred and thirty blood samples of elderly patients with gastric cancer in a hospital were collected as experimental group, and 138 cases of blood DNA of middle-aged and elderly healthy subjects were selected as control group. PCR was used to detect GSTM1 deletion polymorphism in all DNA samples. The statistical software SPSS13.0 was used to analyze the data. Results The detection rate of GSTM1 (-) / GSTM1 (+) was 29.8% / 70.2% in the experimental group and 18.8% / 81.2% in the control group. The difference between the two groups was statistically analyzed There was statistical significance (χ2 = 4.538, P = 0.033 <0.05). Conclusions GSTM1 gene deletion polymorphism is associated with gastric cancer susceptibility in middle-aged and elderly people in Hainan. GSTM1 (-) may be a susceptible genotype in middle-aged and elderly patients with gastric cancer.