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目的：探讨阿德福韦酯联合拉米夫定治疗乙型肝炎肝硬化的临床效果。方法将本院收治的138例乙型肝炎肝硬化患者随机分为两组，各69例。对照组采用常规保肝、纠正水电解平衡及排腹水等常规治疗，观察组在常规治疗基础上采用阿德福韦酯联合拉米夫定治疗。结果治疗后，观察组Child-Pugh评分、ALT、ALB、TBiL水平低于对照组，差异有统计学意义(P<0.05)。结论阿德福韦酯联合拉米夫定治疗乙型肝炎肝硬化能有效终止HBV-DNA在体内复制，降低血清病毒含量，促进肝脏TBiL代谢，改善肝功能。“,”Objective To evaluate clinical efficacy of adefovir dipivoxil combined with lamivudine in the treatment of hepatitis B complicated with liver cirrhosis. Methods 138 patients with hepatitis B complicated with liver cirrhosis in our hospital were randomly divided into two groups,69 cases in each group.Conventional treatment methods including conventional protecting liver,correct the electrolysis of water balance and the row of ascites were used in control group, adefovir dipivoxil combined with lamivudine were applied in observation group on the basis of conventional treatment. Results After treatment,Child-Pugh score,ALT,ALB,TBiL level in observation group was lower than that in control group respectively,with statistical difference (P<0.05). Conclusion Adefovir dipivoxil combined with lamivudine in the treatment of hepatitis B complicated with liver cirrhosis can effectively end the replication of HBV-DNA in body,re-duce the serum virus content,promote TBiL metabolism,improve liver function.