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寻找在放射治疗情况下对正常组织有选择性防护作用的方法,是肿瘤放射学中的迫切任务。过去有人报道,在外源性低氧条件下联合使用辐射防护剂具有良好前景。本工作继续研究了用低氧混合气体和药物低氧加强抗放效价的可能性。实验用体重为26～29克的F_1(CBA-C_(57)Bl)杂种小鼠进行。全身γ线(~(137)Cs)照射是在《》装置上进行的,剂量率为5.5Gy/min。动物于辐照前10分钟和5分钟先后腹腔注入胱胺和5-甲氧色铵蒸馏水溶液,剂量分别为50mg/kg和25
Looking for ways to selectively protect normal tissues from radiation therapy is an urgent task in oncology radiology. In the past it was reported that there is a good prospect for the combined use of radioprotectants in the presence of exogenous hypoxia. This work continues to investigate the possibility of enhancing the anti-putative titer with hypoxia and hypoxia. Experiments were performed with F 1 (CBA-C_ (57) Bl) hybrid mice weighing 26-29 grams. Whole body gamma ray (~ (137) Cs) irradiation was performed on a “” device at a dose rate of 5.5 Gy / min. Animals were injected intraperitoneally with cystamine and 5-methoxytryptamine in distilled water 10 and 10 minutes before irradiation at doses of 50 mg / kg and 25, respectively