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蒽环类抗生素是目前广泛使用的高效广谱抗肿瘤抗生素,但其毒副反应严重影响了临床应用,特别是以阿霉素(ADM)为代表的心脏选择性毒性作用,其发生机制尚不十分明确,临床诊断及防治方法缺乏特异性。现将近3年来有关研究综述如下。 1 阿霉素心脏毒性的机制目前认为主要原理是氧自由基反应、酶和其它蛋白质表达减少、以钙超载及诱生型一氧化氮(NO)产生为代表的物质和能量代谢失常等,其中已达成共识的是阿霉素主要损伤心肌细胞线粒体,近年来细胞凋亡在ADM心肌损害中的意义已受到重视。
Anthracycline is widely used broad-spectrum antitumor antibiotics, but its toxic side effects seriously affect the clinical application, especially with doxorubicin (ADM) as the representative of selective cardiac toxicity, its mechanism is not yet Very clear, the lack of specificity of clinical diagnosis and prevention methods. Now nearly three years of research are summarized below. A mechanism of doxorubicin cardiotoxicity Now the main principle is that the oxygen free radical reaction, reduced expression of enzymes and other proteins, calcium overload and induced nitric oxide (NO) represented by the generation of substances and energy metabolism disorders, etc. It has been agreed that doxorubicin mainly damages the mitochondria of cardiomyocytes, and the significance of apoptosis in the myocardial damage of ADM in recent years has been taken seriously.