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目的:研究运脾复方儿宝颗粒对小儿厌食症动物模型下丘脑CCK8和βEP的调节作用。方法:模拟小儿厌食症的主要病因制作幼龄大鼠厌食模型,用儿宝颗粒治疗,用放射免疫检测技术测定实验动物下丘脑CCK8和βEP的含量。结果:模型动物下丘脑CCK8浓度显著增高(P<0.05),βEP浓度无明显变化(P>0.05);儿宝颗粒治疗组CCK8含量恢复正常,βEP含量显著增高(P<0.01)。结论:儿宝颗粒能明显抑制该模型下丘脑CCK8分泌,同时促进下丘脑βEP分泌。
Objective: To study the regulation of CCK8 and βEP in the hypothalamus of the animal model of pediatric anorexia treated by “Yunpi Compound Erbao Granule”. Methods: To simulate the main cause of pediatric anorexia, an anorexia model was made in young rats and treated with Erbao granule. Radioimmunoassay was used to determine the content of CCK8 and βEP in the hypothalamus of experimental animals. Results: The concentration of CCK8 in hypothalamus of model animals was significantly increased (P <0.05) and the concentration of βEP was not significantly changed (P> 0.05). The content of CCK8 in Erbao Granule treated group returned to normal and the content of βEP increased significantly (P <0.01). Conclusion: Erbao Granule can significantly inhibit the secretion of CCK8 in the hypothalamus and promote the secretion of βEP in the hypothalamus.