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ABCA1是一种介导细胞内过量胆固醇外流到载脂蛋白并将其包装成高密度脂蛋白(HDL)的膜转运蛋白,是调节血浆HDL及细胞内胆固醇水平的重要受体；然而,其具体的作用机制尚未明了。近期研究逐步揭示,ABCA1有可能通过特殊的信号传导通路诱发胆同醇外流；其信号传导作用还体现在抗凋亡、影响细胞骨架蛋白的相互作用等其它方面,本文对ABCA1的脂质调节、表达调控和信号传导等方面的最新研究进行了综述。
ABCA1, a membrane transporter that mediates the outflow of excess cholesterol from cells to apolipoproteins and packages them into high-density lipoproteins (HDLs), is an important receptor that regulates plasma HDL and intracellular cholesterol levels; however, its specific The mechanism of action is unclear. Recent studies have gradually revealed that ABCA1 may induce gallochitolecule outflow through a special signaling pathway; its signal transduction is also reflected in anti-apoptosis and other aspects that affect the interaction of cytoskeletal proteins and other aspects. In this paper, ABCA1 lipid regulation, Expression and regulation and signal transduction aspects of the latest research are reviewed.