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目的了解江苏省人群C反应蛋白(CRP)的水平与传统冠心病(CHD)危险因素的关系。方法通过“江苏省多代谢异常和代谢综合征综合防治研究”资料,比较高敏C反应蛋白(hs-CRP)(hs-CRP:1～2.99 mg/L和≥3 mg/L)与传统CHD危险因素:体重指数(BMI)、吸烟、高血压、高血糖、高胆固醇、高三酰甘油、低高密度脂蛋白胆固醇、体力活动缺乏等的关系。结果高hs-CRP罹患率均随血压、血糖、胆固醇、三酰甘油、BMI、吸烟、体力活动(无、轻、中、重)增加而增高,但当hs-CRP(1～2.99 mg/L)时,传统CHD危险因素中大部分未表现出显著联系;随着Framingham心脏积分(5个危险因素)合并数量增加,高hs-CRP呈明显的等级性变化趋势;logistic回归分析表明,hs-CRP (≥3 mg/L)时,BMI、三酰甘油、高血压、高密度脂蛋白胆固醇、吸烟、血糖的OR值均有统计学意义,但hs-CRP(1～2.99 mg/L)时,传统CHD危险因素的OR估计值大部分无统计学意义;男性中60.98%和女性中59.02%的高CRP可以归因于传统CHD危险因素。结论传统CHD危险因素与hs-CRP水平关系密切,目前在临床上、人群研究中根据CRP水平的高低判断CHD风险的实际意义值得进一步探讨。
Objective To understand the relationship between the level of C-reactive protein (CRP) and the risk factors of coronary heart disease (CHD) in Jiangsu Province. Methods The data of hs-CRP (hs-CRP: 1 ~ 2.99 mg / L and ≥ 3 mg / L) were compared with the traditional data of “prevention and control of multiple metabolic disorders and metabolic syndrome in Jiangsu Province” CHD risk factors: body mass index (BMI), smoking, high blood pressure, high blood sugar, high cholesterol, high triglycerides, low-density lipoprotein cholesterol, lack of physical activity and so on. Results The prevalence of high hs-CRP increased with the increase of blood pressure, blood glucose, cholesterol, triglyceride, BMI, smoking and physical activity (no, ), Most of the traditional CHD risk factors did not show a significant relationship; with the Framingham Cardiac Integral (5 risk factors) combined increased the number of high hs-CRP showed a significant trend of rank; logistic regression analysis showed that hs- CRP (≥3 mg / L), BMI, triglyceride, hypertension, high density lipoprotein cholesterol, smoking, blood glucose OR were statistically significant, but hs-CRP The OR estimates of risk factors for CHD were not statistically significant. 60.98% of men and 59.02% of women with high CRP were attributable to traditional CHD risk factors. Conclusion The risk factors of traditional CHD are closely related to the level of hs-CRP. At present, the practical significance of judging the risk of CHD according to the level of CRP in the clinic and in the population is worth further exploration.