论文部分内容阅读
目的探讨癌胚抗原(CEA)和糖链抗原724(CA724)联合检测对结直肠癌的诊断价值。方法用化学发光法检测结直肠癌患者41例、结直肠良性病变患者46例、健康体检人群101例的血清CEA含量,用电化学发光法检测3组人群的血清CA724水平,统计分析CEA和CA724在结直肠癌诊断中的应用价值。结果结直肠癌患者血清CEA和CA724水平显著高于结直肠良性病变患者及健康体检人群的水平(P<0·05);结直肠良性病变患者血清CEA和CA72-4浓度显著高于健康体检人群的浓度(P<0·05)。单项检测CEA对结直肠癌诊断的敏感度、特异性和准确性分别为58·5%、76·0%、67·8%;CA724为:34·1%、93·4%、65·5%;联合检测CEA和CA724为:68·2%、71·7%、70·1%。结论 CEA和CA724结直肠癌诊断和疗效监测有一定价值,两者联合检测可提高结直肠癌的检出率。
Objective To investigate the diagnostic value of combined detection of carcinoembryonic antigen (CEA) and carbohydrate antigen 724 (CA724) in colorectal cancer. Methods The levels of serum CEA in 41 patients with colorectal cancer, 46 patients with colorectal benign disease and 101 healthy people were detected by chemiluminescence method. The levels of serum CA724 in three groups were detected by electrochemiluminescence assay. The levels of CEA and CA724 In the diagnosis of colorectal cancer value. Results The serum levels of CEA and CA724 in patients with colorectal cancer were significantly higher than those in patients with benign colorectal lesions and healthy people (P <0.05). The concentrations of CEA and CA72-4 in patients with colorectal benign disease were significantly higher than those in healthy people (P <0 · 05). The sensitivity, specificity and accuracy of single detection of CEA in the diagnosis of colorectal cancer were 58.5%, 76.0% and 67.8% respectively; CA724 was 34.1%, 93.4% and 65.5 respectively %; The combined detection of CEA and CA724: 68.2%, 71.7%, 70.1%. Conclusion CEA and CA724 colorectal cancer diagnosis and efficacy monitoring of some value, the combination of the two can increase the detection rate of colorectal cancer.