前已报道,从海南粗榧(Cephalotaxus hainanensis Li)树皮中分离得到海南粗榧内酯(Hainanolide),并测定了它的结构。 海南粗榧内酯对L_(615)、S_(180)、W_(256)、Lewis肺癌、P_(388)和L_(1210)均有活性。这是一种新类型的抗癌活性成分,在药物化学和寻找新抗癌药物的工作中是很值得注意的。Buta等从同属植物Cephalotaxus harringtonia的种子中分得相同的化合物,测定了结构,命名为Harringtonolide,并发现具有抑制植物生长的作用,但未报道有抗癌活性。 It has been reported previously that Hainanolici was isolated from the bark of Cephalotaxus hainanensis Li and its structure was determined. Hainan crude lactone has activity on L_ (615), S_ (180), W_ (256), Lewis lung cancer, P_ (388) and L_ (1210). This is a new type of anti-cancer active ingredient that is very noteworthy in the work of drug chemistry and the search for new anti-cancer drugs. Buta et al. obtained the same compound from the seed of the genus Cephalotaxus harringtonia and determined the structure, named Harringtonolide, and found that it had the effect of inhibiting plant growth, but no anticancer activity was reported.