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目的:了解乳腺恶性肿瘤在河南南阳市区的发病规律和特性。方法:采用SP免疫组化法检测ER,PR,C-erbB-2,p53,PS2,MDR-1在乳腺癌中的表达,并对近5年来422例乳腺恶性肿瘤病例进行统计分析。结果:乳腺恶性肿瘤构成比约为40%,但乳腺癌的外检例数增加了2倍;发病年龄最小22岁,最大81岁,以41岁-50岁组比例最高。年龄<40岁病例占25.6%,表明乳腺恶性肿瘤发病有年轻化趋势。肿瘤类型以浸润性导管癌为主(81.37%),其次是导管原位癌;C-erbB-2表达与ER受体表达呈负相关,ER(-)患者C-erbB-2表达率高,ER(+)患者C-erbB-2表达率低。癌基因C-erbB-2阳性病人,淋巴结转移率较高,C-erbB-2阴性病人淋巴结转移率低,二者有明显差异。结论:南阳地区乳腺癌发病率明显高于国内外研究结果,治疗预后有关的癌基因表达情况与国内外报道基本一致,p53表达偏低,MDR-1表达偏高。
Objective: To understand the incidence and characteristics of breast cancer in Nanyang City, Henan Province. Methods: The expression of ER, PR, C-erbB-2, p53, PS2 and MDR-1 in breast cancer was detected by SP immunohistochemical method, and 422 cases of breast cancer were analyzed statistically in recent 5 years. Results: The constituent ratio of breast cancer was about 40%, but the number of cases of breast cancer increased 2-fold. The age of onset was the smallest at 22 years old and the maximum was 81 years old, with the highest proportion being 41-50 years old. Age <40 years old cases accounted for 25.6%, indicating a trend of younger malignant breast cancer. The type of tumor was infiltrative ductal carcinoma (81.37%), followed by ductal carcinoma in situ. The expression of C-erbB-2 was negatively correlated with the expression of ER receptor. The expression of C-erbB- ER (+) patients with low expression of C-erbB-2. The oncogene C-erbB-2 positive patients had higher rate of lymph node metastasis and lower rate of lymph node metastasis in C-erbB-2 negative patients, with significant difference between the two. Conclusion: The incidence of breast cancer in Nanyang was significantly higher than that of the results at home and abroad. The prognosis-related oncogene expression was basically consistent with the reports at home and abroad. The expression of p53 was low and the expression of MDR-1 was high.