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目的研究珠芽蓼果实粉的亚慢性毒性,并对其安全性做出评价。方法试验设3个实验组和1个饲料对照组,单笼饲养。每日观察并记录动物的一般表现,中毒表现和死亡情况。每周记录1次体重和2次食物摄入量,计算每周及总的食物利用率。连续喂饲90 d,实验中期检查大鼠血常规指标,实验结束时做大鼠血液学、病理学等检查。结果实验期间,各组大鼠均未见明显中毒体征,也未见死亡。实验组动物的血液细胞学检查、血液生化学检查、脏器称量结果等各项检测指标与对照组比较,差异均无统计学意义(P>0.05)。实验组动物的组织病理学未见与试验用样品有关的病理学改变。结论在本实验条件下,未见蓼果实粉对雌、雄大鼠有明显的亚慢性毒性作用。
Objective To study the subchronic toxicity of Polygonum viviparum fruit powder and to evaluate its safety. Methods Experimental set up three experimental groups and a feed control group, a single cage feeding. Daily observation and record of animal’s general performance, poisoning performance and death. Weekly recordings of body weight and 2 food intake were recorded weekly and total food utilization. Continuous feeding 90 d, the middle of the experiment to check the blood parameters of rats, the end of the experiment to do rat hematology, pathology and other tests. Results During the experiment, no obvious signs of poisoning and no death were found in all the rats in each group. The blood cytology, blood biochemical tests and organ weighing test results of the experimental group were not significantly different from those of the control group (P> 0.05). Histopathology of experimental animals No pathological changes associated with the test samples were observed. Conclusion Under the conditions of this experiment, there was no obvious subchronic toxic effect of Polygonum fruit powder on female and male rats.