论文部分内容阅读
1968年Berggard等首先从肾小管病变患者(Wilson病和慢性镉中毒)的尿中分离出β_2微球蛋白(β_2m)。β_2m是由100多种氨基酸的单体多肽组成的蛋白质,其分子量为11800。为人体淋巴细胞所产生,与HLA的A.B.C抗原有关。它广泛存在于血清、脑脊液、初乳、羊水、精液等体液中,恶性肿瘤细胞亦能合成β_2m。近年来对恶性肿瘤病人,血中β_2m值的升高引起重视。有不少学者试图探讨能否把它作为肿瘤的血清
In 1968, Berggard et al. first isolated β 2 microglobulin (β 2 m) from the urine of patients with renal tubular disease (Wilson disease and chronic cadmium poisoning). Β_2m is a protein composed of monomeric peptides of more than 100 amino acids and has a molecular weight of 11800. Produced for human lymphocytes, associated with HLA A.B.C antigen. It is widely present in body fluids such as serum, cerebrospinal fluid, colostrum, amniotic fluid, semen, etc. Malignant tumor cells can also synthesize β 2 m. In recent years, attention has been paid to the increase of blood β 2 m values in patients with malignant tumors. Many scholars have tried to explore whether it can be used as a tumor serum