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目的:观察新血府逐瘀汤对动脉粥样硬化(AS)模型大鼠胸主动脉病理形态学及细胞间黏附分子(ICAM-1)和血管间黏附分子(VCAM-1)表达的影响。方法:SPF级雄性Wistar大鼠50只,随机分5组:空白组、模型组、立普妥组、新血府逐瘀汤低、高剂量组。采用高脂饲料饲养及腹腔注射维生素D3方法复制AS模型。造模成功后给予相应的药物8周。分别观察胸主动脉病理形态学改变及检测病变局部ICAM-1和VCAM-1的表达情况。结果:与空白组比较,模型组ICAM-1和VCAM-1的阳性评分显著升高(P<0.01),新血府逐瘀汤高、低剂量组ICAM-1、VCAM-1的阳性评分较模型组明显降低(P<0.05),与立普妥组比较差异无显著性。结论:新血府逐瘀汤可在一定程度上减少黏附因子的表达以抑制免疫炎症,从而起到抗AS的作用。
Objective: To observe the effect of Xin Xue Fu Zhu Yu Decoction on the pathological morphology of the thoracic aorta and the expression of intercellular adhesion molecule (ICAM-1) and intercellular adhesion molecule (VCAM-1) in the rat model of atherosclerosis (AS). Methods: Fifty SPF male Wistar rats were randomly divided into 5 groups: blank group, model group, Lipitor group, Xinxuefuzhuyu Decoction low and high dose group. AS model was reproduced by feeding high fat diet and intraperitoneal injection of vitamin D3. After the success of modeling given the appropriate drug for 8 weeks. The pathological changes of the thoracic aorta and the expression of ICAM-1 and VCAM-1 in the lesion were observed. Results: Compared with the blank group, the positive scores of ICAM-1 and VCAM-1 in the model group were significantly increased (P <0.01). The positive scores of Xinamuraizhuyu Decoction high and low dose ICAM-1 and VCAM-1 The model group was significantly lower (P <0.05), compared with the Lipitor group was no significant difference. Conclusion: Xin Xue Fu Zhu Yu Decoction can reduce the expression of adhesion factor to a certain extent to inhibit immune inflammation, and thus play an anti-AS role.