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[目的]探讨中药联合阿德福韦酯对多位点变异慢乙肝临床疗效。[方法]84例感染位点变异株慢性乙型肝炎患者,分A、B组,每组42人,A组服用阿德福韦酯10mg/d,B组服用阿德福韦酯10mg/d,同时加服中药方剂。比较观察治疗4周、12周、24周、48周后疗效。[结果]A、B组间在治疗4w、12w、24w、48w时段,ALT复常率比较差异有统计学意义(P<0.01);A、B组48周HBVDNA均数差异有显著性(P<0.05)。疗效无性别差异。[结论]阿德福韦联合中药组在改善多位点变异慢性乙肝患者临床症状、恢复肝功能方面均优于单用阿德福韦酯。
[Objective] To explore the clinical efficacy of traditional Chinese medicine combined with adefovir dipivoxil on multi-locus mutation chronic hepatitis B. [Method] Eighty-four patients with chronic hepatitis B were divided into group A and group B with 42 patients in each group. Group A received adefovir dipivoxil 10 mg / d, group B received adefovir dipivoxil 10 mg / d At the same time plus traditional Chinese medicine prescriptions. Compare the treatment of 4 weeks, 12 weeks, 24 weeks, 48 weeks after treatment. [Results] There was significant difference in the rate of ALT between A group and B group at 4w, 12w, 24w and 48w (P <0.01), and there was a significant difference between the two groups <0.05). No gender differences in efficacy. [Conclusion] adefovir combined with traditional Chinese medicine group is superior to adefovir dipivoxil alone in improving clinical symptoms and recovering liver function in patients with chronic hepatitis B with multi-site mutation.