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目的探讨高同型半胱氨酸(Hcy)血症与急性脑梗死的关系。方法收集124例脑卒中患者为病例组,选择124例与病例组相匹配的无脑卒中者作为对照组,均采用荧光偏振免疫分析法测定血浆Hcy,按发病<24h时血浆Hcy水平将患者分为正常Hcy组、高Hcy组,入院时对病例组进行美国国立卫生研究院卒中量表(NIHSS)评分。结果病例组血浆Hcy水平显著高于对照组,差异有统计学意义(P<0.05);病例组内高同型半胱氨酸血症(HHe)患者入院时神经功能缺损评分与Hcy水平正常患者相比差异有统计学意义(P<0.05)。结论高Hcy血症是脑卒中的独立危险因素,并与急性脑梗死严重程度密切相关。
Objective To investigate the relationship between hyperhomocysteinemia and acute cerebral infarction. Methods A total of 124 stroke patients were selected as the case group. 124 stroke-free matched stroke patients were selected as the control group. Fluorescence polarization immunoassay was used to measure plasma Hcy. According to the plasma Hcy level at 24h, For the normal Hcy group and the high Hcy group, the National Institutes of Health Stroke Scale (NIHSS) was scored on case-group at admission. Results The level of Hcy in the patients was significantly higher than that in the control group (P <0.05). In the patients with high homocysteinemia (HHe), the scores of neurological deficits at hospital admission were similar to those of patients with normal Hcy levels The difference was statistically significant (P <0.05). Conclusion Hyperhomocysteinemia is an independent risk factor for stroke and is closely related to the severity of acute cerebral infarction.