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内啡肽有不少药理作用。它具有镇痛作用,能产生依药和耐药,并与精神疾病也有关。Terenius首先报道急性精神分裂症和躁狂型精神病人的脑脊液中内啡肽的含量升高,其中有些患者的病情感轻时内啡肽含量又降低;Guune用单盲法给慢性妄想型精神分裂症患者静脉注射纳洛酮(0.4mg)后,有4/6患者取消听幻觉。以后又有三家实验室从事这方面的研究,但由于方法学上的限制或所用药物剂量不同,而未能重复上述结果。本文作者应用双盲交叉法观察了纳洛酮治疗精神病幻觉的作用。
Endorphins have many pharmacological effects. It has analgesic effect, can produce drug and drug resistance, and is also related to mental illness. Terenius first reported increased levels of endorphin in cerebrospinal fluid in patients with acute schizophrenia and manic-based psychosis, some of whom also showed diminished levels of endorphins when they were mild; Guune administered chronic blind dementia to schizophrenia Symptomatic patients intravenous naloxone (0.4mg), 4/6 patients to cancel auditory hallucinations. Since then, three more laboratories have conducted research in this area, but the above results could not be repeated due to the methodological limitations or the dose of the drug used. The authors used a double-blind crossover method to observe the effects of naloxone on psychotic hallucinations.