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目的研究甘肃省河西地区抗结核药品不良反应现状及其影响因素。方法选择自2015年1月1日起甘肃省凉州区、民勤县、古浪县、天祝县、甘州区、山丹县、民乐县、高台县、临泽县和肃南县10个县(区)确诊并治疗的1 415例初治活动性肺结核病病例,调查抗结核药品不良反应发生情况,明确其危险因素。结果河西地区抗结核药品不良反应发生率高达48.27%,其中肝损害(8.26%)、消化系统(7.73%)和血液系统(3.09%)发生率较高,不同影响因素性别(χ~2=6.63)、年龄(χ~2=222.06)、文化程度(χ~2=15.53)、BMI(χ~2=76.62)、吸烟(χ~2=9.75)、酗酒(χ~2=88.52)、肝炎(χ~2=86.62)和糖尿病(χ~2=31.55)不良反应的发生率差异有统计学意义(均P<0.05)。结论河西地区抗结核药品不良反应发生率较高,应对抗结核药品的使用加强管理,个体化且合理用药。
Objective To study the status of adverse reactions of antituberculosis drugs in Hexi region of Gansu Province and its influencing factors. Method selection From January 1, 2015, Liangzhou District, Minqin County, Gulang County, Tianzhu County, Ganzhou District, Shandan County, Minle County, Gaotai County, Linze County and Sunan County 10 A total of 1 415 cases of newly diagnosed active tuberculosis cases diagnosed and treated in counties (districts) were investigated. The incidence of adverse reactions of anti-TB drugs was investigated and the risk factors were clarified. Results The incidence of adverse reactions of anti-tuberculosis drugs in Hexi area was as high as 48.27%. The incidence of hepatic damage (8.26%), digestive system (7.73%) and hematological system (3.09%) were higher than those of other influencing factors (χ ~ 2 = 6.63 , Age (χ ~ 2 = 222.06), education level (χ ~ 2 = 15.53), BMI (χ ~ 2 = 76.62), smoking (χ ~ 2 = 9.75), alcohol abuse χ ~ 2 = 86.62) and diabetes (χ ~ 2 = 31.55). There was a significant difference in the incidence of adverse reactions between the two groups (all P <0.05). Conclusion The incidence of adverse reactions of anti-TB drugs in Hexi area is high, and the use of anti-tuberculosis drugs should be strengthened to manage, individualized and rational use of drugs.