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[目的]探讨急性缺血性脑卒中病人入院时血浆脑利钠肽(BNP)水平能否成为急性缺血性脑卒中病人发病后3个月神经功能恢复程度的预测指标。[方法]根据《中国急性缺血性脑卒中诊治指南2010》诊断标准,前瞻性入选88例24 h内发病的急性缺血性脑卒中病人,于入院24 h内检测血浆BNP,将3个月后神经功能恢复良好组与3个月后神经功能恢复较差组进行比较。[结果]发病3个月后神经功能恢复程度与入院时BNP值等级、梗死体积均有显著相关性(P值﹤0.001),3个月后神经功能恢复较差组入院时血浆BNP水平[(884.75±330.07)pg/mL]显著高于3个月后神经功能恢复良好组[(263.27±281.89)pg/mL],P<0.001。入院时血浆BNP水平≥366.40 pg/mL可作为发病3个月后神经功能恢复较差组的预测指标,其敏感性为96.00%,特异性为76.19%。[结论]急性缺血性脑卒中病人入院时血浆BNP水平可作为其发病3个月后神经功能恢复程度的预测因子。
[Objective] To investigate whether plasma brain natriuretic peptide (BNP) levels in acute ischemic stroke patients can be predictors of the recovery of neurological function 3 months after onset of acute ischemic stroke. [Methods] According to the diagnostic criteria of “Guidelines for Diagnosis and Treatment of Acute Ischemic Stroke in China 2010”, 88 patients with acute ischemic stroke within 24 h were prospectively enrolled and plasma BNP levels were measured within 24 h after admission. Blood samples were collected for 3 months The group with good neurological function recovered and the group with poor neurological function recovered after 3 months were compared. [Results] The degree of recovery of neurological function after 3 months of onset was significantly correlated with the level of BNP and the volume of infarction on admission (P <0.001). After 3 months, the level of BNP in admission to hospital with poor neurological function [( 884.75 ± 330.07) pg / mL] was significantly higher than that of the healthy group after 3 months [(263.27 ± 281.89) pg / mL], P <0.001. Plasma BNP level at admission ≥366.40 pg / mL as a predictor of poor neurologic recovery 3 months after onset, with a sensitivity of 96.00% and a specificity of 76.19%. [Conclusions] BNP level in patients with acute ischemic stroke can be used as predictors of the recovery of neurological function 3 months after onset of acute cerebral apoplexy.