临床研究报道当归芍药散(TJ-23)对绝经后妇女的阿耳茨海默型痴呆具有增强认知能力的功效。还有文献报道,TJ-23对大鼠的大脑神经具有保护作用,能减轻抗胆碱能药东莨菪碱引起的大鼠和小鼠学习和记忆障碍。为此,进一步研究了TJ-23对体外培养谷氨酸引起的大鼠小脑颗粒细胞神经元损伤的保护作用。 Clinical studies have reported that Danggui Shaoyao San (TJ-23) has cognitive function enhancing effects on Alzheimer’s dementia in postmenopausal women. It has also been reported in the literature that TJ-23 has a protective effect on the rat’s cerebral nerves, and can reduce learning and memory impairments in rats and mice caused by scopolamine, an anticholinergic drug. Therefore, the protective effect of TJ-23 on glutamate-induced neuronal injury in rat cerebellar granule cells was further studied.