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目的 :评价国产哌拉西林 /三唑巴坦的疗效和安全性。方法 :哌拉西林 /三唑巴坦与替卡西林 /克拉维酸在下呼吸道和腹腔胆道感染中进行随机对照观察 ,其中治疗组 5 4例 ,对照组 5 2例 ;另 5 8例接受哌拉西林 /三唑巴坦治疗的下呼吸道、尿路、皮肤软组织感染和败血症病例系开放组。治疗下呼吸道、腹腔胆道等感染哌拉西林 /三唑巴坦为每次 4.5 g q8h静脉滴注 ,尿路、皮肤软组织感染为 4.5 g bid静脉滴注 ,替卡西林 /克拉维酸均为每次 3.2 g q8h静脉滴注。结果 :哌拉西林 /三唑巴坦治疗下呼吸道感染和腹腔胆道感染的疗效与对照药相仿 ,但其治疗下呼吸道感染的疗效优于替卡西林 /克拉维酸 (P=0 .0 2 ) ,细菌清除率两组相仿 ,两组中均无不良反应发生者。哌拉西林 /三唑巴坦 (包括治疗组和开放组 )治疗上述感染的总有效率为 92 .0 %(10 3/112 ) ,细菌清除率 97.3% (10 8/111) ,不良反应发生率为 1.8% (2 /112 ) ,分别为腹泻及 AL T升高各 1例。结论 :国产哌拉西林 /三唑巴坦治疗常见性细菌感染疗效确切 ,不良反应少而轻微 ,其疗效较替卡西林 /克拉维酸相似或略优 ,安全性与替卡西林 /克拉维酸相仿
Objective: To evaluate the curative effect and safety of domestic piperacillin / tazobactam. Methods: Randomized controlled clinical trials of piperacillin / tazobactam and ticarcillin / clavulanic acid were performed in lower respiratory tract and abdominal biliary tract infection, including 54 in the treatment group and 52 in the control group. Another 58 patients received piperacilli Lower respiratory tract, urinary tract, skin and soft tissue infections and sepsis were treated with Xilin / Tazobactam in the open group. Treatment of lower respiratory tract, abdominal bile duct infections such as piperacillin / tazobactam for each 4.5 g q8h intravenous infusion, urinary tract, skin and soft tissue infections for 4.5 g bid intravenous infusion of ticarcillin / clavulanic acid are Times 3.2 g q8h intravenous drip. Results: The efficacy of piperacillin / tazobactam in the treatment of lower respiratory tract infection and abdominal bile duct infection was similar to that of the reference drug, but the efficacy of piperacillin / tazobactam in the treatment of lower respiratory tract infection was better than that of ticarcillin / clavulanic acid (P = 0.002) , Bacterial clearance rate was similar in both groups, no adverse reactions occurred in both groups. The total effective rate of piperacillin / tazobactam (including the treatment group and the open group) was 92.0% (10 3/112) and the bacterial clearance rate was 97.3% (10 8/111). Adverse reactions occurred The rate was 1.8% (2/112), one case of diarrhea and one case of ALT. CONCLUSION: Domestic piperacillin / tazobactam is effective in treating common bacterial infections with few and minor adverse reactions. Its efficacy is similar to or slightly better than ticarcillin / clavulanic acid. Safety and ticarcillin / clavulanic acid similar