放疗对脆弱的血管系统造成损伤早就引起病理学者的注意。20年前 Rubin 等经过一系列观察提出放射能损伤血管,尤其血管壁是放射损伤的原发因素。Withers 等提出间质细胞的损伤是放疗的限量因素。间质细胞的生存有赖于血管的供应,相反, Radiation damage to the fragile vascular system has long drawn the attention of pathologists. Twenty years ago, Rubin et al. Proposed a series of observations that radiation-damaged blood vessels, especially the vascular wall, are the primary causes of radiation damage. Withers and other proposed interstitial cell injury is the limiting factor of radiation. The survival of stromal cells depends on the supply of blood vessels, on the contrary,