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目的利用Meta分析方法探讨母亲高龄因素与儿童先天性心脏病的关系,为早期预防提供科学依据。方法运用Stata10.0,对1994-2013年国内外有关母亲高龄与儿童先天性心脏病关系的病例对照研究相关文献进行Meta分析。结果纳入文献9篇,累计先天性心脏病病例19 201例,其中母亲为高龄的有3 026例,占15.76%;对照组74371例,其中母亲为高龄的有11 410例,占15.34%。合并OR值为1.13,95%置信区间:1.07~1.18。结论儿童先天性心脏病的发生可能与母亲高龄有关,应提倡育龄妇女选择最佳年龄段生育,降低先心病的发生率。
Objective To explore the relationship between maternal age-related factors and congenital heart disease in children by Meta-analysis, and provide scientific evidence for early prevention. Methods Stata10.0 was used to analyze the literature of case-control studies on the relationship between the elderly and children with congenital heart disease at home and abroad from 1994 to 2013. Meta-analysis was performed. Results A total of 9 articles were included in the literature. A total of 19 201 cases of congenital heart disease were included, of which 3,026 were elderly mothers, accounting for 15.76%. In the control group, 74,371 were cases, of whom 11,410 were elderly mothers, accounting for 15.34%. The combined OR was 1.13, 95% confidence interval: 1.07-1.18. Conclusion The incidence of congenital heart disease in children may be related to the elderly, and women of childbearing age should be advocated to choose the best age of childbearing and reduce the incidence of congenital heart disease.