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目的评估血管性血友病因子(vWF)抗原检测在血友病(vWD)患者和轻中度血友病A患者鉴别诊断中的价值。方法从2010年8月到2015年12月在我中心检测凝血因子Ⅷ活性低于45%,而且根据临床表现及家族史怀疑为血管性血友病的患者77例,用酶联免疫法和免疫比浊法检测vWF抗原。结果检测的77例患者中29例患者VWF抗原水平低于35%,为vWD患者;48例未检出vWF抗原水平降低。其中女性患者16例中11例vWF抗原水平降低(68.75%),诊断为血管性血友病患者的几率要高于男性患者(29.51%),差异有统计学意义(P<0.01)结论凝血因子Ⅷ活性低的患者,特别是女性患者,需要检测vWF抗原水平,筛查是否为vWD。vWF抗原水平检测能很好的满足临床需求,为vWD诊断提供依据,会得到越来越广泛的应用。
Objective To assess the value of detecting vWF antigen in the differential diagnosis of hemophilia (vWD) patients and mild to moderate hemophilia A patients. Methods From August 2010 to December 2015, 77 patients with von Willebrand disease were assayed for less than 45% coagulation factor Ⅷ activity in our center, and 77 patients were von Willebrand disease based on clinical manifestations and family history. ELISA and immunization Turbidimetric assay vWF antigen. RESULTS: Of the 77 patients tested, 29 had VWF antigen levels of less than 35% for vWD patients, and 48 had undetectable vWF antigen levels. Among them, 11 cases of vWF antigen decreased (68.75%) in 16 female patients, the incidence of vWF was higher in male patients than in male patients (29.51%), the difference was statistically significant (P <0.01) .Conclusion Clotting factor Patients with low activity, especially in women, need to be tested for vWF antigen levels and for screening for vWD. vWF antigen level detection can meet the clinical needs well and provide the basis for the diagnosis of vWD, it will be more and more widely used.